URSODEOXYCHOLIC ACID SODIUM SALT
URSODEOXYCHOLIC ACID SODIUM SALT Basic information
- Product Name:
- URSODEOXYCHOLIC ACID SODIUM SALT
- Synonyms:
-
- SODIUM URSODEOXYCHOLATE
- URSODEOXYCHOLIC ACID SODIUM SALT
- 5BETA-CHOLANIC ACID-3ALPHA,7BETA-DIOL SODIUM SALT
- 3ALPHA,7BETA-DIHYDROXY-5BETA-CHOLANIC ACID SODIUM SALT
- 5beta-Cholanic Acid-3alpha,7beta-diol Sodium Salt 3alpha,7beta-Dihydroxy-5beta-cholanic Acid Sodium Salt Ursodeoxycholic Acid Sodium Salt
- CAS:
- 31687-65-7
- MF:
- C24H39NaO4
- MW:
- 414.55
- Mol File:
- Mol File
URSODEOXYCHOLIC ACID SODIUM SALT Chemical Properties
- Melting point:
- >185°C (dec.)
- storage temp.
- Refrigerator
- solubility
- Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
URSODEOXYCHOLIC ACID SODIUM SALT Usage And Synthesis
Description
Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item No. 10011286).1,2 UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.3 It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.4 UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 | 18231) or ethanol in primary rat hepatocytes.5 Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis.WARNING This product is not for human or veterinary use.
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