12(S)-HYDROXY-16-HEPTADECYNOIC ACID Chemical Properties

Boiling point:

432.8±20.0 °C(Predicted)

Density 

0.989±0.06 g/cm3(Predicted)

solubility 

DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml

form 

A crystalline solid

pka

4.78±0.10(Predicted)

12(S)-HYDROXY-16-HEPTADECYNOIC ACID Usage And Synthesis

Description

12(S)-hydroxy-16-Heptadecynoic acid is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a K_i value of 1.8 μM.

Uses

12(S)-Hydroxy-16-heptadecynoic acid ((12S)-12-Hydroxy-15-hexadecynoic acid) is a mechanism-based inhibitor of cytochrome P450 ω-hydroxylase. It inhibits prostaglandin ω-hydroxylase with a Ki value of 1.8 μM.

Definition

ChEBI: 12S-Hydroxy-16-heptadecynoic acid is a long-chain fatty acid.

References

[1] Burger, et al. Mechanism-based inhibitors of prostaglandin w -hydrolase: (R)- and (S)-12-hydroxy-16-heptadecynoic acid and 2,2-dimethyl-12-hydroxy-16-heptadecynoic acid. J. Med. Chem. 36, 1418-1424 (1993).

12(S)-HYDROXY-16-HEPTADECYNOIC ACID(148019-74-3)Related Product Information

• 4-Pentyn-1-ol
• 12(S)-HYDROXY-16-HEPTADECYNOIC ACID
• 15-HEXADECYN-1-OL