4-Pentyn-1-ol Chemical Properties

Melting point:

-24.1°C (estimate)

Boiling point:

154-155 °C (lit.)

Density 

0.904 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.445(lit.)

Flash point:

143 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform, Methanol

pka

14.81±0.10(Predicted)

form 

Liquid

color 

Clear yellow

Specific Gravity

0.904

Water Solubility 

Miscible with water.

BRN 

1736712

InChIKey

CRWVOXFUXPYTRK-UHFFFAOYSA-N

CAS DataBase Reference

5390-04-5(CAS DataBase Reference)

NIST Chemistry Reference

4-Pentyn-1-ol(5390-04-5)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

RIDADR 

1987

WGK Germany 

3

F 

10

HazardClass 

3.2

PackingGroup 

III

HS Code 

29052900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Pentyn-1-ol Usage And Synthesis

Chemical Properties

Clear yellow liquid

Uses

4-Pentyn-1-ol is an alkyne alcohol that is used as an initiator in ring-opening polymerization reactions. 4-Pentyn-1-ol is capable of undergoing cyclosisomerization, and is also used as a reactant in the synthesis of (+)-Serinolamide A, a cannabinoid CB1 receptor agonist.

Application

4-Pentyn-1-ol was used in preparation of 3-pent-4-ynyloxy phthalonitrile. It was also used as starting reagent in stereoselective total synthesis of antimicrobial marine metabolites, ieodomycin A and B.

General Description

Mechanism of (THF)W(CO)₅-promoted endo- and exo-cycloisomerization of 4-pentyn-1-ol was studied.

Synthesis

4-Pentyn-1-ol has been prepared from 4-penten-1-ol by bromination followed by dehydrobromination with alkali.

4-Pentyn-1-ol(5390-04-5)Related Product Information

• Ethynyl estradiol
• 3-Methyl butynol
• 4-Penten-1-ol
• Propargyl alcohol
• L-Propargylglycine HCL
• D-PROPARGYLGLYCINE
• 4-Fluorocinnamic acid
• 5-PHENYL-4-PENTYN-1-OL
• 3,4,4-TRIMETHYL-1-PENTYN-3-OL 98%
• 5-(diethylamino)-3-Pentyn-2-ol,3-Pentyn-2-ol,5-(diethylamino)-
• 1-PHENYL-4-METHYL-1-PENTYN-3-OL
• 3-PENTYN-1-OL 99%,3-PENTYN-1-OL 99+%
• 1-Pentyn-3-ol,98%,1-PENTYN-3-OL
• 2-PENTYN-2-OL,2-Pentyn-1-ol,98+%
• 3-(beta-chlorovinyl)-1-pentyn-3-ol
• 1-Pentyn-3-ol, 3-methyl-,1-Pentyn-3-ol,3-methyl
• 5-DIMETHYLAMINO-2-METHYL-3-PENTYN-2-OL
• Eptaloprost