4-PENTYNOIC ACID Chemical Properties

Melting point:

54-57 °C(lit.)

Boiling point:

110 °C30 mm Hg(lit.)

Density 

1.1133 (rough estimate)

refractive index 

1.3930 (estimate)

Flash point:

75 °C

storage temp. 

2-8°C

pka

4.30±0.10(Predicted)

form 

Crystalline Powder or Flakes

color 

White to beige

Water Solubility 

Soluble in low polarity organic solvents. Soluble in water.

Sensitive 

Light & Air Sensitive & Hygroscopic

BRN 

1742047

InChIKey

MLBYLEUJXUBIJJ-UHFFFAOYSA-N

LogP

0.402 (est)

CAS DataBase Reference

6089-09-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

RTECS 

SC4751000

F 

8-10-23

Hazard Note 

Corrosive

HazardClass 

8

PackingGroup 

III

HS Code 

29161900

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

4-PENTYNOIC ACID Usage And Synthesis

Chemical Properties

white to beige crystalline powder or flakes

Uses

4-Pentynoic Acid is a hypoglycemic agent shown to increase liver tyrosine aminotransferase and plasma corticosterone while decreasing blood sugar in rats.

Uses

4-Pentynoic acid was used:

• as building block for the synthesis of library of eight sequence-defined model oligomers
• in one-pot synthesis of the complex polycyclic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives
• in the synthesis of various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones]
• in the synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene

General Description

4-Pentynoic acid undergoes copper-catalyzed intramolecular cyclizations to form enol lactones. It also reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones.

4-PENTYNOIC ACID(6089-09-4)Related Product Information

• 4-PENTYNOIC ACID
• Cinnamyl bromide
• 2-AMINO-4-PENTYNOIC ACID
• 2-PENTYNOIC ACID
• 4-Pentynoic acid, 2-amino-, (2S)-,(S)-2-AMINO-4-PENTYNOIC ACID
• L-Propargylglycine HCL
• (R)-2-AMINO-4-PENTYNOIC ACID
• (R)-2-aminopent-4-ynoic acid
• (S)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID
• 2-Pentynoic acid ethyl ester
• (R)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID
• FMOC-L-PROPARGYLGLYCINE
• (R)-2-Amino-4-pentynoic acid t-butyl ester
• 5-(4-chlorophenyl)-2-((4-methylphenyl)sulfonyl)-4-pentynoic acid
• 2-n-propyl-4-pentynoic acid
• N-ALPHA-T-BUTOXYCARBONYL-(S)-2-AMINO-4-PENTYNOIC ACID DICYCLOHEXYLAMMONIUM SALT,(S)-2-(BOC-AMINO)-4-PENTYNOIC ACID DICYCLOHEXYLAMINE SALT
• 4-PENTYNOIC ACID 98%
• 3-Pentynoic acid