BISINDOLYLMALEIMIDE III
BISINDOLYLMALEIMIDE III Basic information
- Product Name:
- BISINDOLYLMALEIMIDE III
- Synonyms:
-
- BISINDOLYLMALEIMIDE III
- 3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
- 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
- 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
- Bisindolylmaleimide III, PKC inhibitor
- CAS:
- 137592-43-9
- MF:
- C23H20N4O2
- MW:
- 384.43
- Product Categories:
-
- Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- Mol File
BISINDOLYLMALEIMIDE III Chemical Properties
- Boiling point:
- 708.7±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- solubility
- DMSO: soluble; Methanol: soluble
- form
- A crystalline solid
- pka
- 8.15±0.60(Predicted)
- color
- Brown to reddish brown
BISINDOLYLMALEIMIDE III Usage And Synthesis
Description
Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-
Uses
Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,
Definition
ChEBI: Bisindolylmaleimide III is a member of maleimides and a member of indoles. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.
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