ANTI-NUMB Chemical Properties

storage temp. 

-20°C

form 

buffered aqueous solution

biological source

rabbit

Safety Information

Storage Class

10 - Combustible liquids

ANTI-NUMB Usage And Synthesis

Uses

Anti-NUMB antibody may be used in immunoblotting.

Biological Activity

Numb is an antagonist of the notch. It plays a role in the neural differentiation in the central nervous system (CNS) and self-renewal of neural stem cells (NSCs). Loss of Numb function in mice results in embryonic lethality and precocious neuronal differentiation. It has been suggested th at a switch in Numb isoform expression is a critical step in cortical development. The proliferation of neural crest stem cells (NCSCs) is promoted by the proline-rich region (PRRL) of the isoform 1 and 3. The ectopic expression of Numb2 or Numb4 isoforms devoid of the prolinerich region mediates enhanced neuronal differentiation. The loss of Numb may impact the epithelial-to-mesenchymal transition (EMT).