Difenoconazole Chemical Properties

Melting point:

76°C

Boiling point:

220°C

Density 

1.4916 (rough estimate)

vapor pressure 

3.3 x l0^-8 Pa (25 °C)

refractive index 

1.6140 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

Chloroform: Slightly Soluble,Methanol: Slightly Soluble

pka

2.94±0.12(Predicted)

Water Solubility 

3.3 mg/L (20 ºC)

Merck 

13,3160

BRN 

9073356

LogP

4.300

CAS DataBase Reference

119446-68-3(CAS DataBase Reference)

NIST Chemistry Reference

Difenoconazole(119446-68-3)

EPA Substance Registry System

Difenoconazole (119446-68-3)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-41-43-50-20/22

Safety Statements 

26-36/37/39-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

RTECS 

XZ4380000

Hazardous Substances Data

119446-68-3(Hazardous Substances Data)

Toxicity

LD50 in rats (mg/kg): 1453 orally; in rabbits: >2010 dermally (Ruess)

MSDS

• Language:English Provider:Difenoconazole

Difenoconazole Usage And Synthesis

Description

Difenoconazole is a kind of triazole-type fungicide. It is a broad-spectrum triazole fungicide. It takes effect through acting as the inhibitor of sterol 14α-demethylase, blocking the biosynthesis of sterol. Through inhibiting the sterol biosynthesis process, it inhibits the mycelia growth and germination of pathogens by spores, ultimately suppressing the proliferation of fungi. Difenoconazole has been extensively used in a wide range of crops in many countries due to its ability to control various fungal diseases. It is also one of the most important and widely-used pesticides for disease control in rice.

Uses

Difenoconazole is a fungicide with broad-range activity, protecting yield and quality by foliar application or seed treatment. It provides long-lasting and curative activity against Ascomycetes, Basidiomycetes and Deuteromycetes. It is used against disease complexes in grapes, pome fruit, stone fruit, potatoes, sugar beet, oilseed rape, banana, ornamentals and various vegetable crops. It is also used as a seed treatment against a range of pathogens in wheat and barley.

Uses

Pestanal is an fungicide that exhibits a broad spectrum of activities against a wide variety of fungi including members of the Aschomycetes, Basidomycetes and Deuteromycetes families.

Uses

Agricultural fungicide.

Definition

ChEBI: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.

Agricultural Uses

Fungicide: For suppression of fungi diseases in crops and seeds.

Trade name

CGA 169374®; DIVIDEND®; DIVIDEND® EXTREME FUNGICIDE; HELIX®; SCORE®; TECHNICAL CGA-169374®

Metabolic pathway

There is limited published information on the metabolism of difenoconazole. It is slowly dissipated in soils, and metabolism in plants involves rupture of the triazole linkage or oxidation of the phenyl ring followed by conjugation.

Degradation

Difenoconazole is stable to hydrolysis and is thermally stable to 150 °C. DT₅₀ of difenocoazole in natural sunlight was 145 days.

References

Kwok, Iris M‐Y., and R. Thomas Loeffler. "The biochemical mode of action of some newer azole fungicides." Pest Management Science 39.1 (1993): 1-11.
Wang, K., J. X. Wu, and H. Y. Zhang. "Dissipation of difenoconazole in rice, paddy soil, and paddy water under field conditions." Ecotoxicology and environmental safety 86 (2012): 111-115.

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