Aluminium phosphate Chemical Properties

Melting point:

1500 °C

Density 

2.56 g/mL at 25 °C (lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Very slightly soluble in water, practically insoluble in alcohol. It dissolves in dilute solutions of mineral acids and alkali hydroxides.

form 

Powder

color 

White

Specific Gravity

2.566

Water Solubility 

Insoluble

Merck 

14,358

Solubility Product Constant (Ksp)

pKsp: 20.01

Exposure limits

ACGIH: TWA 1 mg/m3

Dielectric constant

6.0（Ambient）

InChI

InChI=1S/Al.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+3;/p-3

InChIKey

ILRRQNADMUWWFW-UHFFFAOYSA-K

SMILES

[Al+3].P([O-])([O-])([O-])=O

CAS DataBase Reference

7784-30-7(CAS DataBase Reference)

EPA Substance Registry System

Monoaluminum phosphate (7784-30-7)

Safety Information

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3260 8/PG 2

WGK Germany 

1

RTECS 

TB6450000

TSCA 

Yes

HazardClass 

8

HS Code 

28352990

Toxicity

LD50 oral in mouse: > 5gm/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Aluminium phosphate Usage And Synthesis

Description

Aluminium phosphate occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaAl(PO4)(OH)]; augelite, [Al2(PO4)(OH)3]; lazulite, [(Mg,Fe)Al2(PO4)2(OH)2]; variscite [(Al,Fe3+)(PO4)•2H2O]; and wavellite, [Al3(OH)3•(PO4)2•5H2O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.

Chemical Properties

Aluminum orthophosphate is a white crystalline solid which is often used in liquid or gel form

Chemical Properties

Aluminum phosphate adjuvant is a white hydrogel that sediments slowly and forms a clear supernatant.

Physical properties

White powdery solid (rhombic plate); the mineral berlinite (AlPO₄) has hexagonal quartz-like structure; refractive index 1.546; mp > 1,500°C; density 2.566 g/cu³; insoluble in water and alcohol; Ksp 9.83x10^-10 very slightly soluble in HCl or HNO3.

Occurrence

The compound occurs in nature as the mineral, berlinite. Also, it occurs in nature in minerals, amblygonite, [NaA_l(PO₄)(OH)]; augelite, [Al₂(PO₄)(OH)₃]; lazulite, [(Mg,Fe)Al₂(PO₄)₂(OH)₂]; variscite [(Al,Fe³⁺)(PO₄)?₂H₂O]; and wavellite, [Al₃(OH)₃?(PO4)₂?5H₂O]. It is used as flux for ceramics; as cement in combination with calcium sulfate and sodium silicate; and in the manufacture of special glasses. It is also used in dried gel and therapeutically as an antacid.

Uses

Antacid; vaccine adjuvant

Uses

As a flux for ceramics, preparation of dental cement, cement with calcium sulfate and sodium silicate, special glasses, as gel in pharmacy.Aluminum phosphate is used as catalysts, molecular sieves, flux for ceramics and as a gel in pharmacy. It is employed in the preparation of dental cement, emollients and fire-resistant coating. It plays an important role as an anti-fouling agent in textile industry.

Preparation

It is prepared by treating sodium aluminate with phosphoric acid.

Production Methods

Aluminum phosphate adjuvant is formed by the reaction of a solution of aluminum chloride and phosphoric acid with alkali hydroxide.

brand name

Phosphaljel (Wyeth-Ayerst).

General Description

A colorless liquid. Insoluble in water. Corrosive to metals and tissue.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

An acid. The resulting aqueous solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions.

Hazard

Solutions are corrosive to tissue.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

Aluminum phosphate adjuvant is used in parenteral human and veterinary vaccines.It activates Th2 immune responses, including IgG and IgE antibody responses.

Clinical Use

Phalu Gel's main active ingredient is aluminum Phosphorus. Aluminum Phosphate works to reduce excess stomach acid. This gel suspension, when taken to the stomach, will form a protective layer on the surface of the gastrointestinal mucosa, similar to the effect of mucus or mucosal protective factors to help cover the stomach from the impact of fluids. The aluminum phosphate layer in the stomach has a smooth dispersion effect, going to the ulcers in the stomach and making them heal faster, making the patient feel more comfortable and less painful. Aluminum Phosphorus, when used, does not affect the intestinal absorption of Phosphorus. Phalu-Gel will quickly reduce the pain of stomach ulcers and the discomfort of excess acid, help heal the ulcers quickly, and make the patient feel comfortable right away.Aluminum hydroxide, aluminum phosphate, and potassium aluminum sulfate (alum) are used as adjuvants in vaccines designed to stimulate systemic immunity. Aluminum salts are used in DPT, pneumocccal conjugate, hepatitis A, papilloma, anthrax, and rabies vaccines. Like other systemic adjuvants, they form an insoluble depot and slowly release the antigen, which stimulates an antibody response.

Safety Profile

Corrosive to the eyes, skin, and mucous membranes. When heated to decomposition it emits toxic fumes of POx. Used as an antacid and as a cement component, flux for ceramics, dental cement, glass, and gels. See also ALUMINUM COMPOUNDS and PHOSPHATES

Safety

Aluminum phosphate adjuvant is intended for use in parenteral vaccines and is generally regarded as safe. It may cause mild irritation, dryness, and dermatitis on skin contact. It may also cause redness, conjunctivitis, and short-term mild irritation on eye contact. Ingestion of large amounts of aluminum phosphate adjuvant may cause respiratory irritation with nausea, vomiting, and constipation. Inhalation is unlikely, although the dried product may cause respiratory irritation and cough. Type I hypersensitivity reactions following parenteral administration have also been reported.

Potential Exposure

Used as a flux in ceramics; in dental cements; in the manufacture of special glasses, paints and varnishes, cosmetics; making pulp and paper; as an antacid.

storage

Aluminum phosphate adjuvant is stable for at least 2 years when stored at 4–308℃ in well-sealed inert containers. It must not be allowed to freeze as the hydrated colloid structure will be irreversibly damaged.

Shipping

UN1760 Corrosive liquids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required. UN3260 Corrosive solid, acidic, inorganic, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name Required.

Incompatibilities

The point of zero charge is related directly to the Al : P atomic ratio. Therefore, the substitution of additional phosphate groups for hydroxyl groups will lower the point of zero charge. Substitution of carbonate, sulfate, or borate ions for hydroxyl groups will also lower the point of zero charge.

Incompatibilities

A strong oxidizer; keep away from combustible materials. Violent reaction with reducing agents; strong bases. Material is an inorganic acid and will react, possibly violently, with bases; corrosive to metals, some plastics and body tissues

Regulatory Status

GRAS listed. Accepted for use in human and veterinary vaccines in Europe and the USA. The limits for use in human vaccines are 0.85 mg aluminum/dose (FDA) and 1.25 mg aluminum/dose (WHO). There are no established limits for use in veterinary vaccines. Reported in the EPA TSCA Inventory.

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