TN-16 Chemical Properties

Melting point:

182～185℃

Boiling point:

532.7±50.0 °C(Predicted)

Density 

1.249±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ≥17mg/mL

form 

powder

pka

10.53±0.40(Predicted)

color 

white to tan

InChI

1S/C19H18N2O2/c1-13(20-15-10-6-3-7-11-15)17-18(22)16(21-19(17)23)12-14-8-4-2-5-9-14/h2-11,16,20H,12H2,1H3,(H,21,23)/b17-13-

InChIKey

KWSXUGYAGMSUTN-LGMDPLHJSA-N

SMILES

C\C(Nc1ccccc1)=C2\C(=O)NC(Cc3ccccc3)C2=O

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

43-50/53

Safety Statements 

36/37-60-61

RIDADR 

UN 3077 9 / PGIII

WGK Germany 

3

Storage Class

11 - Combustible Solids

Hazard Classifications

Aquatic Acute 1
Skin Sens. 1

TN-16 Usage And Synthesis

Uses

TN-16 is an antitumor drug that blocks microtubule assembly. Tubulin inhibitor.

Biological Activity

3-(l-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16), a tenuazonic acid derivative, is a synthetic antitumor agent which arrests mitosis of tumor cells at metaphase. It is a colchicine site binding agent and a powerful autophagy flux inhibitor th at could be used as a conventional autophagy inhibitor with anti-cancer potential in pre-clinical trials.', 'Inhibitor of microtubule assembly', 'TN-16 is a synthetic compound th at blocks the assembly, and promotes the dissociation of microtubules. It can prevent the b-TrCP-mediated degradation of the transcription factor Gli2, leading to the up-regulation of BMP-2 and supporting a role for microtubule formation in the regulation of bone formation.

TN-16(33016-12-5)Related Product Information

• Vincristine sulfate
• ANSAMITOCIN P-3
• DOLASTATIN 15
• NOCODAZOLE
• MYOSEVERIN
• TN-16
• 2,4-Pyrrolidinedione