LDC7559
LDC7559 Basic information
- Product Name:
- LDC7559
- Synonyms:
-
- Acetamide, N-[2-(2-methoxyphenyl)-4H,10H-pyrazolo[5,1-c][1,4]benzoxazepin-7-yl]-
- LDC7559
- Inhibitor,Pyroptosis,LDC7559,inhibit,LDC 7559,LDC-7559
- N-(2-(2-Methoxyphenyl)-4,10-dihydrobenzo[f]pyrazolo[5,1-c][1,4]oxazepin-7-yl)acetamide
- LDC7559, 10 mM in DMSO
- CAS:
- 2407782-01-6
- MF:
- C20H19N3O3
- MW:
- 349.38
- Mol File:
- 2407782-01-6.mol
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LDC7559 Chemical Properties
- Boiling point:
- 596.3±50.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 125 mg/mL (357.78 mM)
- pka
- 14.44±0.20(Predicted)
- form
- Solid
- color
- White to light yellow
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LDC7559 Usage And Synthesis
Description
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages.
in vitro
LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.
LDC7559Supplier
Nanjing Xinmeihe Pharmaceutical Co., Ltd. Gold
- Tel
- 025-57672321 13739186949
- 2548785915@qq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Chuzhou KeMail Chemical Technology Co., Ltd
- Tel
- 0550-5196001 15000891977
- wj520wjxby@126.com
Shanghai Han-Xiang Chemical Co., Ltd.
- Tel
- 15971444841
- amber@biochempartner.com