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5-Amino-4-methylpyrimidine

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5-Amino-4-methylpyrimidine Basic information

Product Name:
5-Amino-4-methylpyrimidine
Synonyms:
  • 5-AMINO-4-METHYLPYRIMIDINE
  • 5-AMIO-4-METHYLPYRIMIDINE
  • 5-Pyrimidinamine, 4-methyl- (9CI)
  • 5-Pyrimidinamine, 4-methyl
  • 4-Methylpyrimidin-5-amine
  • 4-Methyl-5-pyrimidinamine
  • (4-methylpyrimidin-5-yl)amine
  • Pyrimidine, 5-amino-4-methyl-
CAS:
3438-61-7
MF:
C5H7N3
MW:
109.13
Product Categories:
  • Heterocycle-Pyrimidine series
  • PYRIMIDINE
Mol File:
3438-61-7.mol
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5-Amino-4-methylpyrimidine Chemical Properties

Melting point:
151-151.5 °C
Boiling point:
246.8±20.0 °C(Predicted)
Density 
1.155±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.21±0.16(Predicted)
Appearance
White to yellow Solid
InChI
InChI=1S/C5H7N3/c1-4-5(6)2-7-3-8-4/h2-3H,6H2,1H3
InChIKey
DQNDDUOCVSWTOW-UHFFFAOYSA-N
SMILES
C1=NC=C(N)C(C)=N1
CAS DataBase Reference
3438-61-7(CAS DataBase Reference)
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5-Amino-4-methylpyrimidine Usage And Synthesis

Uses

5-Amino-4-methylpyrimidine is a pharmaceutical intermediate compound. Its structural features include a methyl group and an amino group attached to the 4th and 5th positions, respectively, on the pyrimidine ring. This substance can be used in the preparation of anticancer inhibitory compounds.

Synthesis

When 5-amino-2,4- dichloro-6-methylpyrimidine was hydrogenated over 10% palladium-on-charcoal in the presence of excess magnesium oxide a 31 % yield of 5-amino-4-methylpyrimidine was obtained[1].

References

[1] C. G. Overberger, W. J. E., Irving C. Kogon. (1954). Derivatives of 5-Amino-4-methylpyrimidine. Journal of the American Chemical Society, 76 7, 1953–1954. https://doi.org/10.1021/ja01636a069

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