L-692,585
L-692,585 Basic information
- Product Name:
- L-692,585
- Synonyms:
-
- L-692,585
- L-692
- 3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide
- 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide
- Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
- 585
- L 692585,L692585
- CAS:
- 145455-35-2
- MF:
- C32H37N7O3
- MW:
- 567.68
- Mol File:
- 145455-35-2.mol
L-692,585 Chemical Properties
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 25 mM in ethanol
- form
- Powder
- color
- White to off-white
L-692,585 Usage And Synthesis
Uses
L-692,585 shows potent and selective GH-secretory activity in several species including human.
Definition
ChEBI: 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide is a peptide.
Biological Activity
Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (K i = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.
in vivo
L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release[3].
L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo[3].
| Animal Model: | Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)[3] |
| Dosage: | 0.01, 0.1 mg/kg |
| Administration: | I.v. once daily for 2 weeks |
| Result: | Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident. |
storage
Desiccate at -20°C
L-692,585Supplier
- Tel
- 821-50328103-801 18930552037
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- Tel
- 888-539-0666
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- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Tel
- info@bocsci.com
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
L-692,585(145455-35-2)Related Product Information
- 1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one
- 3-Amino-2,3,4,5-Tetrahydro-1H-1-benzazepin-2-one
- 1-BENZYL-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- 1H-1-BENZAZEPIN-3-AMINE, 2,3,4,5-TETRAHYDRO-
- 2,3,4,5-Tetrahydro-1H-benzo[b]azepine
- N-(1-METHYL-3-PHENYLPROPYL)ISOVALERAMIDE
- 5-BIPHENYL-2-YL-2H-TETRAZOLE
- (R)-3-AMINO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE
- 2H-1-BENZAZEPIN-2-ONE, 1,3,4,5-TETRAHYDRO-1-METHYL-
- L-692,585
- 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE