2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties

Boiling point:

542.9±50.0 °C(Predicted)

Density 

1.461±0.06 g/cm3(Predicted)

form 

Solid

pka

10.63±0.40(Predicted)

color 

Off-white to gray

2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Usage And Synthesis

Uses

Lenalidomide-F is a E3 ligase ligand for LWY713. LWY713 is a PROTAC-class FLT3 degrader (DC50 = 0.64 nM), which selectively induces FLT3 degradation via cereblon and proteasome-dependent pathways[1].

IC 50

Cereblon

References

[1] Liu W et al. Discovery of LWY713 as a potent and selective FLT3 PROTAC degrader with in vivo activity against acute myeloid leukemia. Eur J Med Chem. 2023 Nov 19;264:115974. DOI:10.1016/j.ejmech.2023.115974

2,6-Piperidinedione, 3-(4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-(2359705-88-5)Related Product Information

• 2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-1-methyl-
• 1-N-Methyl Lenalidomide
• 3-(4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
• 2,6-Piperidinedione, 3-(1,3-dihydro-4-hydroxy-1-oxo-2H-isoindol-2-yl)-1-methyl-
• 3-(4-Bromophenyl)piperidine-2,6-dione
• 3-(4-hydroxy-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione
• 3-(4-Ethynyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione