Basic information Safety Supplier Related

FOSPHENYTOIN

Basic information Safety Supplier Related

FOSPHENYTOIN Basic information

Product Name:
FOSPHENYTOIN
Synonyms:
  • FOSPHENYTOIN
MF:
C16H15N2O6P
MW:
0
Mol File:
Mol File
More
Less

FOSPHENYTOIN Usage And Synthesis

Clinical Use

Fosphenytoin sodium is a soluble pro-drug disodium phosphate ester of phenytoin (142 mg/mL) that was developed as a replacement for parenteral phenytoin sodium to circumvent the pH and solubility problems associated with parenteral phenytoin sodium formulations. Unlike phenytoin, fosphenytoin is freely soluble in aqueous solutions and is rapidly absorbed by the IM route. It is rapidly metabolized (conversion half-life, 8–15 minutes) to phenytoin by in vivo phosphatases. Therapeutic free (unbound) and total plasma phenytoin concentrations are consistently attained following IM or IV administration of fosphenytoin. It is administered IV following benzodiazepines for control of status epilepticus or whenever there is a need to rapidly achieve therapeutic plasma concentrations. Severe bradycardiac adverse events to fosphenytoin, including some fatalities, have been reported. A dose reduction in patients who are elderly or have renal or hepatic impairment has been suggested.

FOSPHENYTOINSupplier

Zen Pharma Pvt. Ltd.
Tel
08068442298Ext 308
Hapto Pharmaceuticals Private Limited
Tel
09394280828
CARBONE SCIENTIFIC CO.,LTD
Tel
+44(0)870 486 8629
Email
sales@carbonesci.com
3B Scientific Corporation
Tel
847.281.9822
Email
sales@3bsc.com
ecochem international chemical broker
Tel
+45 45 42 34 36
Email
export@ecochem.dk
More
Less

FOSPHENYTOIN()Related Product Information