2-Octanone Chemical Properties

Melting point:

-16 °C

Boiling point:

173 °C(lit.)

Density 

0.819 g/mL at 25 °C(lit.)

vapor pressure 

1.8-2.614hPa at 20-25℃

FEMA 

2802 | 2-OCTANONE

refractive index 

n20/D 1.416(lit.)

Flash point:

133 °F

storage temp. 

Sealed in dry,2-8°C

solubility 

0.9g/l

form 

Liquid

color 

Clear colorless to very slightly yellow

Odor

at 10.00 % in dipropylene glycol. earthy weedy natural woody herbal

Odor Type

earthy

Water Solubility 

0.9 g/L

Merck 

14,4711

JECFA Number

288

BRN 

635843

Dielectric constant

7.4（100℃）

Stability:

Stable. Incompatible with strong oxidizing agents. Flammable.

LogP

1.95-2.37 at 25℃

CAS DataBase Reference

111-13-7(CAS DataBase Reference)

NIST Chemistry Reference

2-Octanone(111-13-7)

EPA Substance Registry System

2-Octanone (111-13-7)

Safety Information

Hazard Codes 

Xn

Risk Statements 

21-10

Safety Statements 

36/37-16

RIDADR 

UN 1224 3/PG 3

WGK Germany 

1

RTECS 

RH1484000

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29141990

Hazardous Substances Data

111-13-7(Hazardous Substances Data)

Toxicity

Both the acute oral LD₅₀ in rats and the acute dermal LD₅₀ in rabbits exceeded 5 g/kg (Moreno, 1973).

MSDS

• Language:English Provider:2-Octanone
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Octanone Usage And Synthesis

Synthesis

1-Octyne (7.5 g) and formic acid (100 mL) were heated in an oil bath at 100 ºC until all starting material was consumed. The progress of the reaction was monitored by GC analysis of the reaction solution. Quantitative GC analysis at the end of the reaction (6 h) indicated 92% yield of 2-octanone. The cooled reaction mixture was taken up with CH2Cl2 (170 mL), and the solution was washed with water, sodium carbonate solution, and water, dried over MgSO4, and evaporated in vacuo. The residue was distilled (bp 171–173 ºC) to give 2-octanone (7.42 g, 85%).

Reference: Menashe, N.; Reshef, D.; Shvo, Y. J. Org. Chem. 1991, 56, 2912–2914.

References

[1]Bangs, William E., and G. A. Reineccius. "Influence of Dryer In feed Matrices on the Retention of Volatile Flavor Compounds During Spray Drying." Journal of Food Science 47.1(1982):254-259. Kida, T, et al. "New cleavable surfactants derived from glucono-1,5-lactone. " Journal of the American Oil Chemists’ Society 71.7(1994):705-710.
[2]Tan, Guan Huat, and Lukman Bola Abdulra'uf. "Recent developments and applications of microextraction techniques for the analysis of pesticide residues in fruits and vegetables." Pesticides-Recent Trends in Pesticide Residue Assay. InTech, 2012.

Description

2-Octanone has a floral and bitter, green, fruity (unripe apple) odor with a bitter camphoraceous taste. May be synthesized by the oxidation of methyl hexyl carbinol with K2Cr2O7 and sulfuric acid; also by oxidation of 2-octanol over zinc oxide at 330 - 340°C.

Chemical Properties

2-Octanone has a floral and bitter, green, fruity (unripe apple) odor and bitter, camphoraceous taste. Insoluble in water; solublein alcohol, hydrocarbons, ether, esters, etc. Com-bustible.

Occurrence

Reported found in apple, apricot, banana, cranberry, grape, raisin, papaya, peach, raspberry, strawberry, leek, peas, clove, wheat bread, many cheeses, butter, milk, cooked egg, yogurt, caviar, fatty fish, meats, beer, hop oil beer, cognac, rum, grape wines, cocoa, coffee, tea, roasted filberts and peanuts, pecans, potato chips, oats, soybean, olive, beans, walnut, trassi, mushroom, fig, rice, buckwheat, quince, sweet corn, corn oil, malt, wort, krill, Bourbon vanilla, mountain papaya, shrimp, crab, crayfish, clam, truffle, maté and mastic gum oil.

Uses

2-Octanone may be used as an analytical reference standard for the quantification of the analyte in sugar-cane spirits and rum samples and whey protein concentrate using chromatography based techniques.

Uses

2-Octanone is used in perfumes, high-boiling solvent, especially for epoxy resin coatings and in leather finishes. It is used in flavoring, odorant. It can act as antiblushing agent for nitrocellulose lacquers.

Production Methods

2-Octanone can be produced by oxidation of methyl hexyl carbinol, 2-octanol, or 1-octene or by reductive condensation of acetone with pentanol. Commercial samples can have a purity of 98%.

Preparation

By oxidation of methyl hexyl carbinol with K2Cr2O7 and sulfuric acid; also by oxidation of 2-octanol over zinc oxide at 330 to 340°C.

Definition

ChEBI: A methyl ketone that is octane substituted by an oxo group at position 2.

Aroma threshold values

Detection: 41 to 62 ppb

Taste threshold values

Taste characteristics at 10 ppm: dairy, waxy, cheese, woody, mushroom and yeast.

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 5924, 1991 DOI: 10.1021/jo00020a040
Tetrahedron Letters, 26, p. 2107, 1985 DOI: 10.1016/S0040-4039(00)94791-9

General Description

2-Octanone is a volatile flavor compound reported to be found in blue cheese, acerola fruit, blue crab and cray fish.

Industrial uses

Methyl n-hexyl ketone is used as solvent for vinyl compounds and dyes and is suitable for dispersing dyes in light-weight petroleum oils for newsprint inks.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoned route. A sktn irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use foam, alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes. See also ETHER and KETONES.

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