Basic information Description Uses Side effects Toxicity Safety Supplier Related
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benzatropine

Basic information Description Uses Side effects Toxicity Safety Supplier Related

benzatropine Basic information

Product Name:
benzatropine
Synonyms:
  • benzatropine
  • Benaztropine
  • NISTC86135
  • (1S,5R)-3α-(Diphenylmethoxy)tropane
  • exo-Benztropine
  • (1β,3α,5β)-3-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
  • (1β,5β)-3α-(Diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
  • C06846
CAS:
86-13-5
MF:
C21H25NO
MW:
307.4293
Mol File:
86-13-5.mol
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benzatropine Chemical Properties

Boiling point:
447.93°C (rough estimate)
Density 
1.0505 (rough estimate)
refractive index 
1.5614 (estimate)
pka
10.54±0.40(Predicted)
EPA Substance Registry System
8-Azabicyclo[3.2.1]octane, 3-(diphenylmethoxy)-8-methyl-, (3-endo)- (86-13-5)
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Safety Information

Hazardous Substances Data
86-13-5(Hazardous Substances Data)
Toxicity
LD50 scu-mus: 60 mg/kg JMPCAS 4,215,61
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benzatropine Usage And Synthesis

Description

Benztropine, with the chemical formula 3alpha-diphenylmethoxytropane, is a tropane-based dopamine inhibitor used for the symptomatic treatment of Parkinson's disease. It is a combination molecule between a tropane ring, similar to cocaine, and a diphenyl ether from the dialkylpiperazines determined to be a dopamine uptake inhibitor since 1970. 

Uses

Benzatropine is used to reduce extrapyramidal side effects of antipsychotic treatment. Benzatropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor, and may alleviate rigidity and bradykinesia.Benzatropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face.

Side effects

These are principally anticholinergic:Dry mouth;Blurred vision;Cognitive changes;Drowsiness;Constipation;Urinary retention;Tachycardia;Anorexia;Severe delirium and hallucinations (in overdose).

Toxicity

The oral LD50 of benztropine is reported to be of 940 mg/kg in rats.In the presence of overdose with benztropine, it has been observed symptoms of circulatory collapse, cardiac arrest, respiratory depression, respiratory arrest, psychosis, shock, coma, seizure, ataxia, combativeness, anhidrosis, hyperthermia, fever, dysphagia, decreased bowel sounds and sluggish pupils.

Uses

Antiparkinsonian.

Definition

ChEBI: Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to re uce parkinsonism and akathisia side effects of antipsychotic treatments.

brand name

Cogentin (Merck).

Safety Profile

Poison by subcutaneous andintravenous routes. When heated to decomposition itemits toxic fumes of NOx.

benzatropineSupplier

LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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info@efebio.com
TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
Dayang Chem (Hangzhou) Co.,Ltd.
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571-88938639 +8617705817739
Email
info@dycnchem.com
TargetMol Chemicals Inc.
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4008200310
Email
marketing@tsbiochem.com