2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90% Chemical Properties

Melting point:

81-87 °C

Boiling point:

253.0±42.0 °C(Predicted)

Density 

1.057±0.06 g/cm3(Predicted)

solubility 

Soluble in benzene, chloroform, dichloromethane, ether, methanol and toluene.

pka

10.99±0.60(Predicted)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26

RIDADR 

UN 3335

WGK Germany 

3

2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90% Usage And Synthesis

Uses

2-(Trimethylsilyl)ethanesulfonamide is a source of nucleophilic nitrogen that can react in manifold ways with electrophiles prior to removal of SES group with fluoride ion. It participates in the following reactions: Preparation of N-Sulfonylimines, Mitsunobu Reactions, Azaglycosylation Chemistry, Preparation of Sulfodiimides, Preparation of (N-SES-imino)phenyliodinane etc.

Uses

2-Trimethylsilylethanesulfonyl amide is a useful reagent for introduction of a SES-protected nitrogen functionality, which can be cleaved with fluoride ion.

Preparation

2-(Trimethylsilyl)ethanesulfonamide is prepared by reaction of 2-(trimethylsilyl) ethanesulfonyl chloride (accessible from the commercially available sodium salt of the corresponding sulfonic acid or starting from vinyl trimethylsilane) with gaseous ammonia (eq 1).

2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%(125486-96-6)Related Product Information

• Ethanesulfonamide
• (2-MERCAPTOETHYL)TRIMETHYLSILANE
• 2-(TRIMETHYLSILYL)ETHANESULFONAMIDE, 90%