Basic information Safety Supplier Related

2-NITROBENZYL CHLORIDE

Basic information Safety Supplier Related

2-NITROBENZYL CHLORIDE Basic information

Product Name:
2-NITROBENZYL CHLORIDE
Synonyms:
  • 1-Nitro-2-(chloromethyl)benzene
  • 2-(Chloromethyl)nitrobenzene, alpha-Chloro-2-nitrotoluene
  • 2-Nitrobenzyl chloride 99%
  • 2-NITROBENZYL CHLORIDE
  • A-CHLORO-O-NITROTOLUENE
  • 2-NitrobenzylChloride98%
  • à-chloro-2-nitrotoluene
  • α-chloro-2-nitrotoluene
CAS:
612-23-7
MF:
C7H6ClNO2
MW:
171.58
EINECS:
210-300-5
Mol File:
612-23-7.mol
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2-NITROBENZYL CHLORIDE Chemical Properties

Melting point:
46-48 °C (lit.)
Boiling point:
127-133 °C/10 mmHg (lit.)
Density 
1,556 g/cm3
refractive index 
1.5557 (estimate)
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
ethanol: soluble98%
form 
Crystals, Crystalline Powder or Chunks
color 
Yellow to tan
Water Solubility 
Soluble in acetone, alcohol benzene, diethyl ether, and ethanol (98%). Insoluble in water.
BRN 
388396
Stability:
Stable. Incompatible with bases, moisture, acohols, oxidizing agents, amines. Corrodes steel.
CAS DataBase Reference
612-23-7(CAS DataBase Reference)
EPA Substance Registry System
o-Nitrobenzyl chloride (612-23-7)
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Safety Information

Hazard Codes 
C
Risk Statements 
34-36
Safety Statements 
26-36/37/39-45-27
RIDADR 
UN 3261 8/PG 2
WGK Germany 
3
RTECS 
XS9092000
19-21
HazardClass 
8
PackingGroup 
II
HS Code 
29049090

MSDS

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2-NITROBENZYL CHLORIDE Usage And Synthesis

Chemical Properties

liquid

Uses

2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate.

Uses

2-Nitrobenzyl chloride was used in the synthesis of S-(2-nitrobenzyl)cysteine which was inserted into human erythropoietin. 2-Nitrobenzyl chloride was used to prepare 4,4′-dinitrostillbene.

General Description

Pale yellow crystals. Insoluble in water. Is thermally unstable.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Lachrymator. Causes irritation on contact. Hazardous decomposition products. Mutagen.

Fire Hazard

2-NITROBENZYL CHLORIDE is combustible.

Biochem/physiol Actions

2-Nitrobenzyl chloride reacts with N-methyldiethanolamine and further reaction of the resulting quaternary diol with thionyl chloride at room temperature yields nitrobenzyl mustard quaternary salts.

2-NITROBENZYL CHLORIDESupplier

Fuxin Pharmaceutical
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