2-NITROBENZYL CHLORIDE Property

Melting point:

46-48 °C (lit.)

Boiling point:

127-133 °C/10 mmHg (lit.)

Density 

1,556 g/cm³

refractive index 

1.5557 (estimate)

Flash point:

>230 °F

storage temp. 

Store below +30°C.

solubility 

ethanol: soluble98%

form 

Crystals, Crystalline Powder or Chunks

color 

Yellow to tan

Water Solubility 

Soluble in acetone, alcohol benzene, diethyl ether, and ethanol (98%). Insoluble in water.

BRN 

388396

Stability:

Stable. Incompatible with bases, moisture, acohols, oxidizing agents, amines. Corrodes steel.

CAS DataBase Reference

612-23-7(CAS DataBase Reference)

EPA Substance Registry System

o-Nitrobenzyl chloride (612-23-7)

Safety

Hazard Codes 

C

Risk Statements 

34-36

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

RTECS 

XS9092000

F 

19-21

HazardClass 

8

PackingGroup 

II

HS Code 

29049090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-NITROBENZYL CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

liquid

Uses

2-Nitrobenzyl chloride has been used to introduce the photo labile 2-nitrobenzyl protecting group for the phenolic OH group of tyrosine. It is used as a pharmaceutical intermediate.

Uses

2-Nitrobenzyl chloride was used in the synthesis of S-(2-nitrobenzyl)cysteine which was inserted into human erythropoietin. 2-Nitrobenzyl chloride was used to prepare 4,4′-dinitrostillbene.

General Description

Pale yellow crystals. Insoluble in water. Is thermally unstable.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Lachrymator. Causes irritation on contact. Hazardous decomposition products. Mutagen.

Fire Hazard

2-NITROBENZYL CHLORIDE is combustible.

Biochem/physiol Actions

2-Nitrobenzyl chloride reacts with N-methyldiethanolamine and further reaction of the resulting quaternary diol with thionyl chloride at room temperature yields nitrobenzyl mustard quaternary salts.