Bizelesin
Bizelesin Basic information
- Product Name:
- Bizelesin
- Synonyms:
-
- 1,3-Bis[2-[[[(8S)-8β-chloromethyl-3,6,7,8-tetrahydro-4-hydroxy-1-methylbenzo[1,2-b:4,3-b']dipyrrol]-6-yl]carbonyl]-1H-indol-5-yl]urea
- NSC-615291
- U-77779
- (8S,8'S)-6,6'-[Carbonylbis(iMino-1H- indole-5,2-diylcarbonyl)]bis[8-(chloroMethyl)-3,6,7,8-tetrahydro-1-Methylbe
- N,N'-Bis[2-[[(1S)-1-(chloroMethyl)-1,6-dihydro-5-hydroxy-8-Methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea
- Bizelesin
- 1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]urea
- Urea, N,N'-bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]-
- CAS:
- 129655-21-6
- MF:
- C43H36Cl2N8O5
- MW:
- 815.7
- Product Categories:
-
- Chiral Reagents
- Indole Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 129655-21-6.mol
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Bizelesin Chemical Properties
- Density
- 1.604±0.06 g/cm3(Predicted)
- pka
- 10.06±0.40(Predicted)
- form
- Solid
- color
- Off-white to yellow
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Bizelesin Usage And Synthesis
Uses
As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both si ngle-strand lesions and double-strand DNA cross-links. liferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
BizelesinSupplier
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