5-ACETAMIDOINDOLE Chemical Properties

Melting point:

117-118 °C(Solv: acetonitrile (75-05-8))

Boiling point:

461.2±18.0 °C(Predicted)

Density 

1.290±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

15.59±0.43(Predicted)

Appearance

White to off-white Solid

Safety Information

HS Code 

2933998090

5-ACETAMIDOINDOLE Usage And Synthesis

Synthesis

General method (10): 5-Aminoindole (1.0 eq.) and triethylamine (3.6 eq.) were dissolved in dichloromethane (10 mL, corresponding to 1.182 mmol of raw material) and acetyl chloride (1.2 eq.) was added slowly. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was poured into water and extracted three times with dichloromethane. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by fast silica gel column chromatography using 7:3 hexane/ethyl acetate as eluent afforded 5-acetamidoindole (Intermediate 17A/-(1/-/-indol-5-yl)acetamide, Intermediate 17) as a clear oil (177 mg, 1.016 mmol, 85% yield).1H NMR (400 MHz, CDCl3) δ 8.27 ( bs, 1H), 7.80 (s, 1H), 7.30 (d, J = 8.5 Hz, 2H), 7.20 (dd, J = 8.8, 2.0 Hz, 2H), 6.50 (s, 1H), 2.18 (s, 3H).

References

[1] Patent: WO2016/200339, 2016, A1. Location in patent: Page/Page column 93-94
[2] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 344 - 367

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