Datopotamab
Datopotamab Basic information
- Product Name:
- Datopotamab
- Synonyms:
-
- Datopotamab
- Research Grade Datopotamab (DHC43302)
- Datopotamab (anti-TROP2)
- Research Grade Datopotamab
- CAS:
- 2267989-53-5
- MW:
- 0
- Mol File:
- Mol File
Datopotamab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
Datopotamab Usage And Synthesis
Uses
Datopotamab (CDP7657) is a humanized anti trophoblast cell surface antigen 2 (TROP2) antibody. Datopotamab can generate antibody drug conjugates (ADC) (HY-141598) with DNA topoisomerase I inhibitor Deruxtecan (HY-13631E). Datopotamab can be used in the study of triple negative breast cancer and non-small cell lung cancer[1].
in vivo
Datopotamab deruxtecan (Dato-DXd; 6 mg/kg) shows potent antitumor activity with tumor regression in several TROP2-expressing xenograft tumors including NSCLC patient-derived xenograft (PDX) models. Safety profiles of Datopotamab deruxtecan in rats and cynomolgus monkeys are acceptable[1].
References
[1] Okajima D, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Dec;20(12):2329-2340. DOI:10.1158/1535-7163.MCT-21-0206
[2] Daisuke Okajima, et al. Datopotamab Deruxtecan, a Novel TROP2-directed Antibody-drug Conjugate, Demonstrates Potent Antitumor Activity by Efficient Drug Delivery to Tumor Cells. Mol Cancer Ther. 2021 Aug 19. DOI:10.1158/1535-7163.MCT-21-0206
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