Nicotredole
Nicotredole Basic information
- Product Name:
- Nicotredole
- Synonyms:
-
- Nicotredole
- tryptamide
- N-(2-(1H-Indol-3-yl)ethyl)nicotinaMide
- N-[2-(3-indolyl)ethyl]nicotinamide
- 3-Pyridinecarboxamide, N-[2-(1H-indol-3-yl)ethyl]-
- N-[2-(1H-indol-3-yl)ethyl]pyridine-3-carboxamide
- anti-inflammatory,Nicotredole,analgesic,ulcerogenic,inhibit,Inhibitor
- CAS:
- 29876-14-0
- MF:
- C16H15N3O
- MW:
- 265.31
- Mol File:
- 29876-14-0.mol
Nicotredole Chemical Properties
- Boiling point:
- 408.53°C (rough estimate)
- Density
- 1.0944 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: 25 mg/mL (94.23 mM)
Nicotredole Usage And Synthesis
Biological Activity
Nicotredole (Tryptamide) is an orally active anti-inflammatory analgesic. It showed significant anti-inflammatory effects comparable to Phenylbutazone.
in vitro
Nicotredole inhibits prostaglandin synthetase activity in vitro.
in vivo
Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema.
It reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice.
Nicotredole (ip) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively.
Nicotredole (po) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively.
Nicotredole (25 mg/kg; po or ip) undergoes fast absorption (t 1/2 =4.92-17.5 min) and elimination (t 1/2 =55.72-74.52 min), can reach C max (11-13 μg/cm 3 ) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg?h/cm 3 ).
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Nicotredole(29876-14-0)Related Product Information
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- N,N-DIETHYLNICOTINAMIDE
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- N-(2-INDOL-3-YLETHYL)(2-(4-METHYLPHENYLTHIO)(3-PYRIDYL))FORMAMIDE
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- (2-(4-(TERT-BUTYL)PHENOXY)(3-PYRIDYL))-N-(2-INDOL-3-YLETHYL)FORMAMIDE