Adibendan
Adibendan Basic information
- Product Name:
- Adibendan
- Synonyms:
-
- Adibendan
- 5,7-Dihydro-7,7-dimethyl-2-(pyridin-4-yl)pyrrolo[2,3-f]benzimidazol-6(1H)-one
- BM-14478
- Pyrrolo[2,3-f]benzimidazol-6(3H)-one, 5,7-dihydro-7,7-dimethyl-2-(4-pyridinyl)-
- Adibendan, 10 mM in DMSO
- 7,7-Dimethyl-2-(pyridin-4-yl)-3H,5H,6H,7H-imidazo[4,5-F]indol-6-one
- CAS:
- 100510-33-6
- MF:
- C16H14N4O
- MW:
- 278.314
- Mol File:
- 100510-33-6.mol
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Adibendan Chemical Properties
- Melting point:
- 285-288 °C(Solv: methanol (67-56-1))
- Density
- 1.302±0.06 g/cm3(Predicted)
- pka
- 9.72±0.40(Predicted)
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Adibendan Usage And Synthesis
Uses
Adibendan (BM 14478), a benzimidazole derivative, is an orally active, selective phosphodiesterase III (PDE III) activity inhibitor (IC50=2.0 μM). Adibendan has IC50 values more than 60-fold higher for the inhibition of PDE I or II. Adibendan is a new cardiotonic agent[1].
References
[1] T Bethke, et al. Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts. Naunyn Schmiedebergs Arch Pharmacol. 1988 May;337(5):576-82. DOI:10.1007/BF00182735
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