Dichloroacetic acid methyl ester
Dichloroacetic acid methyl ester Basic information
- Product Name:
- Dichloroacetic acid methyl ester
- Synonyms:
-
- Methyl dichloroacetate solution
- 1,1-Dichloro-2-methoxy-2-oxoethane
- Dichloroacetic acid methyl
- Methyl dichloroacetate, synthesis grade
- Methyl dichloroacetate,purum
- TwoMethyl chloroacetate
- dichloro-aceticacimethylester
- ethanoicacid,dichloro-,methylester
- CAS:
- 116-54-1
- MF:
- C3H4Cl2O2
- MW:
- 142.97
- EINECS:
- 204-146-8
- Product Categories:
-
- Alpha sort
- Pharmaceutical Intermediates
- H-MAlphabetic
- 500 Series Drinking Water Methods
- EPA
- Method 552
- C2 to C5
- Carbonyl Compounds
- Esters
- M
- META - METH
- Pesticides&Metabolites
- Pyrans
- bc0001
- Mol File:
- 116-54-1.mol
Dichloroacetic acid methyl ester Chemical Properties
- Melting point:
- -52 °C (lit.)
- Boiling point:
- 143 °C (lit.)
- Density
- 1.381 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.442(lit.)
- Flash point:
- 176 °F
- storage temp.
- room temp
- solubility
- 4g/l
- form
- Liquid
- color
- Clear colorless
- PH
- 3.8 (4g/l, H2O, 20℃)
- Water Solubility
- Slightly soluble
- BRN
- 1747542
- CAS DataBase Reference
- 116-54-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetic acid, dichloro-, methyl ester(116-54-1)
- EPA Substance Registry System
- Acetic acid, 2,2-dichloro-, methyl ester (116-54-1)
Safety Information
- Hazard Codes
- Xn,Xi,F
- Risk Statements
- 20-36/37/38-40-38-11
- Safety Statements
- 26-36-37/39-16-24-9
- RIDADR
- UN 2299 6.1/PG 3
- WGK Germany
- 3
- RTECS
- AG6625000
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29154000
MSDS
- Language:English Provider:Dichloroacetic acid methyl ester
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ALFA
Dichloroacetic acid methyl ester Usage And Synthesis
Chemical Properties
clear colorless liquid
Uses
Organic intermediate.
Uses
Dichloroacetic Acid Methyl Ester is used in the preparation of telechelics and block copolymers through living radical polymerization.
Uses
Methyl dichloroacetate may be used:
- in the diastereoselctive synthesis of bicyclic chlorocyclopropane
- as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate
- as reagent during CrCl2-induced olefination of aldehydes
Synthesis Reference(s)
Journal of the American Chemical Society, 90, p. 5307, 1968 DOI: 10.1021/ja01021a065
The Journal of Organic Chemistry, 28, p. 1133, 1963
General Description
A colorless liquid with an ethereal odor. Combustible. Flash point 176°F. Corrosive to metals and tissue. Used to make other chemicals.
Air & Water Reactions
Decomposed by water to dichloroacetic acid, a corrosive material with evolution of heat [USCG, 1999].
Reactivity Profile
Dichloroacetic acid methyl ester produces toxic fumes of phosgene and HCl when heated [USCG, 1999].
Hazard
Strong irritant to tissue. Forms corrosiveproducts on hydrolysis, keep dry.
Health Hazard
Extremely destructive to the eyes, nose, throat, and upper respiratory tract. May be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.
Fire Hazard
Special Hazards of Combustion Products: Produces toxic fumes of phosgene and HCl.
Safety Profile
Poisonous irritant to the skin, eyes, and mucous membranes. Hydrolyzes upon contact with moisture to form a product corrosive to tissue. See also DICHLOROACETIC ACID and ESTERS. Dangerous; when heated to decomposition it emits hghly toxic fumes of phosgene and Cl-.
Dichloroacetic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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Dichloroacetic acid methyl ester(116-54-1)Related Product Information
- DICHLOROACETIC ANHYDRIDE
- DICHLOROMETHOXYACETIC ACID METHYL ESTER
- DALAPON-METHYL ESTER
- Dichloroacetic acid methyl ester
- Ethyl trichloroacetate
- ETHYL DICHLOROACETATE
- DIISOPROPYL DICHLOROMALONATE
- Vinyl trichloroacetate
- ERBON
- TRICHLOROACETIC ANHYDRIDE
- Methyl trichloroacetate
- Chloroacetic acid
- Methyl acetate
- Methyl chloroacetate
- Dichloroacetic acid
- TRICHLOROACETIC ACID LAURYL ESTER(C12)
- PENTACHLOROPHENYL DICHLOROACETATE
- TRICHLOROACETIC ACID OCTYL ESTER(C8)