(+/-)-N-3-Benzylnirvanol Chemical Properties

Melting point:

134-136°C

Density 

1.190±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

8.02±0.70(Predicted)

form 

Solid

color 

White to Off-White

(+/-)-N-3-Benzylnirvanol Usage And Synthesis

Description

(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol. (+)-N-3-benzylnirvanol and (–)-N-3-benzylnirvanol are inhibitors of the cytochrome P450 (CYP) isoform CYP2C19 (K_is = 0.25 and 5.3 μM, respectively). (±)-N-3-Benzylnirvanol (20 mg/kg, i.p.) lowers plasma levels of cholesterol in mice.

Chemical Properties

White Solid

Uses

It is a potent and selective human CYP2C19 inhibitor

References

[1] HISASHI SUZUKI. (+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.[J]. Drug Metabolism and Disposition, 2002, 23 1: 235-239. DOI: 10.1124/dmd.30.3.235
[2] JAMES H. MAGUIRE  Iris H H  Akula R Murthy. Hypolipidemic activity of antiepileptic 5-phenylhydantoins in mice[J]. European journal of pharmacology, 1985, 117 1: Pages 135-138. DOI: 10.1016/0014-2999(85)90483-2

(+/-)-N-3-Benzylnirvanol(93879-40-4)Related Product Information

• Hydantoin
• ETHOTOIN
• (+/-)-N-3-Benzylnirvanol
• (S)-MEPHENYTOIN
• (R)-(-)-N-3-Benzylnirvanol
• (S)-(+)-N-3-Benzylnirvanol