Amcinafide
Amcinafide Basic information
- Product Name:
- Amcinafide
- Synonyms:
-
- Amcinafide
- 9-Fluoro-11β,21-dihydroxy-16α,17-[[(R)-1-phenylethylidene]bis(oxy)]pregna-1,4-diene-3,20-dione
- CAS:
- 7332-27-6
- MF:
- C29H33FO6
- MW:
- 496.572
- Mol File:
- 7332-27-6.mol
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Amcinafide Usage And Synthesis
Originator
Amcinafide,Onbio Inc.
Uses
Anti-inflammatory.
Manufacturing Process
1 ml 72% perchloric acid was added to a suspension of 4 g triamcinolone in 100 ml of fresh distilled acetophenone and the mixture was stirred at a room temperature before all triamcinolone solved (for about 2 hours). The solution was neutralized with help of 8 ml of 1.1 N sodium hydroxide and sufficient quantity of sodium bicarbonate. Then chloroform and water were added. Organic layer was separated and concentrated in vacuum. The residue was recrystallized from acetone-hexane and thoroughly washed from acetophenone with hexane. Triamcinolone acetophenide (amicinafide) was prepared. It had MP: 281°-283°C (decomp.);αD 23 = +23°. (c = 0.98 in CHCl3).
Therapeutic Function
Antiinflammatory, Antiallergic
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