Nitracrine Chemical Properties

Melting point:

134-135°

Boiling point:

462.71°C (rough estimate)

Density 

1.2155 (rough estimate)

refractive index 

1.6700 (estimate)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

pKa1 6.45; pKa2 8.8(at 25℃)

form 

Solid

color 

Brown to reddish brown

Nitracrine Usage And Synthesis

Uses

Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells[1][2][3].

Definition

ChEBI: Nitracrine is a member of acridines.

References

[1] Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49(2):215-23. DOI:10.1038/bjc.1984.34
[2] Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81. DOI:10.1016/0306-3623(94)00143-b
[3] Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32. DOI:10.1016/j.jphotobiol.2004.04.005

Nitracrine(4533-39-5)Related Product Information

• 4-(3-AMINOPROP-1-YL)AMINOQUINOLINE
• Nitracrine
• 4-AMINO-5-NITROQUINOLINE
• 4-Acridinecarboxylic acid, 9-((3-(dimethylamino)propyl)amino)-1-nitro- , methyl ester
• 1-AMINOACRIDINE