Posatirelin
Posatirelin Basic information
- Product Name:
- Posatirelin
- Synonyms:
-
- Posatirelin
- N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2
- RGH-2202
- N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
- BRN 6006446
- BRN6006446
- BRN-6006446
- Posatirelinum
- CAS:
- 78664-73-0
- MF:
- C17H28N4O4
- MW:
- 352.432
- Mol File:
- 78664-73-0.mol
Posatirelin Chemical Properties
- Melting point:
- 214-216°
- alpha
- D25 -80.2° (c = 1 in acetic acid)
- Boiling point:
- 739.6±60.0 °C(Predicted)
- Density
- 1.214±0.06 g/cm3(Predicted)
- pka
- 13.56±0.20(Predicted)
Posatirelin Usage And Synthesis
Pharmacological Study
Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic deficit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a significant improvement in intellectual performance, orientation, motivation and memory as compared to controls. The drug was well tolerated.
Description
Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.
Uses
Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.
Definition
ChEBI: Posatirelin is an oligopeptide.