Robalzotan
Robalzotan Basic information
- Product Name:
- Robalzotan
- Synonyms:
-
- Robalzotan
- Robalzotan [inn]
- Unii-I18m56ogme
- (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamidehydrochloride
- NAD 299
- (R)-3-(DicyclobutylaMino)-8-fluorochroMan-5-carboxaMide
- NAD 299 hydrochloride (Robalzotan)
- NAD 299 hydrochloride
- CAS:
- 169758-66-1
- MF:
- C18H23FN2O2
- MW:
- 318.39
- Mol File:
- 169758-66-1.mol
Robalzotan Chemical Properties
- Boiling point:
- 429.9±45.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at RT
- pka
- 15.72±0.40(Predicted)
Robalzotan Usage And Synthesis
Uses
NAD 299 Hydrochloride is a selective, high affinity 5-HT1A antagonist, used in psychotropic drug development.
Biological Activity
Selective, high affinity 5-HT 1A receptor antagonist (K i = 0.6 nM in vitro ).
in vivo
Robalzotan (1-100 μg/kg; i.v.) significantly increases the activity of such neurons at 5 μg/kg in rats, and reverses the acute inhibitory effect of citalopram (HY-121203) (300 μg/kg i.v.) or paroxetine (HY-122272) (100 μg/kg, i.v.) on the activity of 5-HT neurons in the dorsal raphe nucleus in rats[1].
Robalzotan (5, 50 μg/kg; i.v.) increases the firing rate of the 5-HT cells[1].
Robalzotan (2-100 μg/kg; i.v.) occupies 5-HT1A receptors in a dose-dependent in monkeys[2].
Robalzotan (0.3; 1 and 3 μmol/kg s.c) causes a dose-dependent increase of extracellular ACh levels in the rat FC[3].
IC 50
5-HT1A Receptor
RobalzotanSupplier
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 021-60343070
- Tel
- 0571-87396432
- sales@jhechem.com
- Tel
- 21-619849051-1 18521059765
- synchempharma@aliyun.com
- Tel
- 021-54338626 18017892860
- sales@tubepharm.com