4-(2-PHENYLETH-1-YNYL)BENZALDEHYDE Chemical Properties

Melting point:

102 °C

Boiling point:

364.2±25.0 °C(Predicted)

Density 

1.14±0.1 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

crystalline solid

color 

Light yellow

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2912290090

4-(2-PHENYLETH-1-YNYL)BENZALDEHYDE Usage And Synthesis

Synthesis

4-Formylphenylboronic acid (0.5 mmol), phenylacetylene (0.6 mmol), dichloromethane (2 mL), Catalyst 3 (2 mol%), silver oxide (Ag2O, 1.0 mmol), and potassium acetate (KOAc, 1.0 mmol) were sequentially added to the Schlenk tube. The reaction mixture was stirred at 35 °C for 24 h under argon protection. Upon completion of the reaction, excess dichloromethane was removed by rotary evaporation and the residue was purified directly by silica gel column chromatography (eluent was petroleum ether or mixed petroleum ether/ethyl acetate solvent) to afford the target product, 4-(phenylalkynyl)benzaldehyde (32d, Table 1, entry 11) (99 mg, 96% yield). The product was a white solid, melting point: 98-100 °C; 1H NMR (400 MHz, CDCl3) δ 9.99 (s, 1H), 7.84 (d, J = 7.8 Hz, 2H), 7.66 (d, J = 8.0 Hz, 2H), 7.56 (dd, J = 3.4, 2.9 Hz, 2H), 7.37 (s, 3H); 13C NMR ( 100 MHz, CDCl3) δ 191.6, 135.3, 132.0, 131.7, 129.6, 128.9, 128.43, 128.41, 122.4, 93.5, 88.5.

References

[1] Tetrahedron, 2014, vol. 70, # 35, p. 5980 - 5985
[2] Transition Metal Chemistry, 2017, vol. 42, # 7, p. 579 - 585
[3] Catalysis Science and Technology, 2014, vol. 4, # 5, p. 1276 - 1285

4-(2-PHENYLETH-1-YNYL)BENZALDEHYDE(57341-98-7)Related Product Information

• Benzaldehyde
• 4-(2-PHENYLETH-1-YNYL)BENZALDEHYDE OXIME
• 4-PHENYLETHYNYLPHTHALIC ANHYDRIDE
• 4-PHENYLETHYNYLPHTHALIC DIMETHYL ESTER
• 4-FLUORO-4'-(PHENYLETHYNYL)BENZOPHENONE
• 3-PHENYL-1-[4-(2-PHENYLETH-1-YNYL)PHENYL]PROP-2-EN-1-ONE
• RARECHEM AL BI 0963
• 4-(2-PHENYLETH-1-YNYL)BENZALDEHYDE
• 4-PHENYLETHYNYL-BENZOIC ACID
• 1-[4-(2-PHENYLETH-1-YNYL)PHENYL]ETHAN-1-ONE
• 3-(2-CHLOROPHENYL)-1-[4-(2-PHENYLETH-1-YNYL)PHENYL]PROP-2-EN-1-ONE
• 1-[4-(2-PHENYLETH-1-YNYL)PHENYL]-3-(3-THIENYL)PROP-2-EN-1-ONE
• RARECHEM AL BF 0963
• 3-(4-METHOXYPHENYL)-1-[4-(2-PHENYLETH-1-YNYL)PHENYL]PROP-2-EN-1-ONE
• 4-PHENYLETHYNYLPHTHALIC ACID