9-Aminocamptothecin Chemical Properties

Melting point:

142.0-145.0 °C

Boiling point:

819.6±65.0 °C(Predicted)

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

solubility 

≤1mg/ml in DMSO;1mg/ml in dimethyl formamide

form 

powder to crystal

pka

11.23±0.20(Predicted)

color 

Light yellow to Yellow to Orange

Merck 

14,431

InChIKey

FUXVKZWTXQUGMW-FQEVSTJZSA-N

CAS DataBase Reference

91421-43-1(CAS DataBase Reference)

Safety Information

RTECS 

UQ0490500

HS Code 

29349990

9-Aminocamptothecin Usage And Synthesis

Uses

9-Amino Camptothecin is a derivative of Camptothecin (C175150), as antitumor agent.

Definition

ChEBI: 9-Aminocamptothecin is a pyranoindolizinoquinoline.

Biological Activity

9-amino camptothecin is a topoisomerase i inhibitor [1][2].dna topoisomerases relax dna torsional strain generated during replication, transcription, recombination, repair, and chromosome condensation. the relaxation of dna supercoiling by topoisomerase i is enabled by a mechanism of controlled rotation around a transient dna single-strand break. camptothecin (cpt) is isolated from the bark of the chinese tree camptotheca accuminata [3].9-amino camptothecin, a water-soluble camptothecin analogue, is a topoisomerase i inhibitor. in human ht-29 colon adenocarcinoma, 9-amino camptothecin (9-ac) exhibited cytotoxicity with ic50 value of 19 nm. 9-ac also induced dna damage in whole cells and nuclei at a concenstration of 85 nm and 21 nm, respectively [1].9-amino camptothecin had greater activity than camptothecin against human tumour xenografts, including lewis lung carcinoma and b16 melanoma. 9-ac had entered phase ii trials. in patients with advanced solid tumours, 9-amino camptothecin exhibited anti-tumor activity [1][2].

References

[1]. rothenberg, m.l. topoisomerase i inhibitors: review and update. annals of oncology 8(9), 837-855 (1997).
[2]. dancey j, eisenhauer ea. current perspectives on camptothecins in cancer treatment. br j cancer. 1996 aug;74(3):327-38.
[3]. drwal mn1, agama k, wakelin lp, et al. exploring dna topoisomerase i ligand space in search of novel anticancer agents. plos one. 2011;6(9):e25150.

9-Aminocamptothecin(91421-43-1)Related Product Information

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