7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Chemical Properties

Boiling point:

813.7±65.0 °C(Predicted)

Density 

1.51±0.1 g/cm3(Predicted)

pka

9.08±0.40(Predicted)

form 

Solid

color 

White to off-white

7-ETHYL-10-HYDROXYCAMPTOTHECIN,98% Usage And Synthesis

Chemical Properties

Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Camptotheca acuminata.

Uses

12-Ethyl-9-hydroxycamptothecin is a derivative of Camptothecin. Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC50 of 679 nM[1].

References

[1] Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. J Med Chem. 1995;38(3):395-401. DOI:10.1021/jm00003a001

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