2,5-DIMETHYLANISOLE Chemical Properties

Melting point:

90-92 °C

Boiling point:

190 °C (lit.)

Density 

0.965 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.514(lit.)

Flash point:

151 °F

storage temp. 

Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Almost colorless

Specific Gravity

0.965

BRN 

774604

CAS DataBase Reference

1706-11-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

24/25-26

WGK Germany 

3

HS Code 

29093090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,5-DIMETHYLANISOLE Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOWISH LIQUID

Uses

2,5-Dimethylanisole was used to investigate the temperature dependence of spin-rotational relaxation rate of methyl C-13 in 2, 5-dimethylaniline.

General Description

2,5-Dimethylanisole acts as photoexcited donor and undergoes different non-radiative transitions in the presence of the acceptor 2-nitrofluorene in ethanol rigid glassy matrix at 77K.

Synthesis

General procedure for the synthesis of 2,5-dimethylanisole from 2,5-dimethylphenol and dimethyl sulfate: Step 1: 2,5-dimethylphenol (50 g, 410 mmol) and potassium carbonate (68 g, 490 mmol) were dissolved in acetone (600 mL) at room temperature, followed by the addition of dimethyl sulfate (31.02 g, 246 mmol). The reaction mixture was heated and refluxed for 9 h. The progress of the reaction was monitored by TLC and it was found that the starting material was still present. Dimethyl sulfate (31.02 g, 246 mmol) was added additionally and the reaction was continued to reflux for 9 hours. Upon completion of the reaction, the mixture was filtered and acetone was removed using a rotary evaporator. The resulting oil was stirred with 20% sodium hydroxide solution (100 mL) for 10 minutes. The organic layer was washed with water (2 x 500 mL) until the aqueous layer was neutral. The organic layer was dried over sodium sulfate and concentrated in vacuum to give 45.5 g of 2-methoxy-1,4-dimethylbenzene in 81% yield. 1H NMR (CDCl3) δ ppm: 2.2 (3H, s, CH3), 2.34 (3H, s, CH3), 3.82 (3H, s, OCH3), 6.65 (1H, s, Ar-H), 6.7 (1H, d, J = 7.2Hz, Ar-H), 7.03 (1H, d, J = 7.2Hz, Ar-H).

References

[1] Patent: WO2010/59549, 2010, A1. Location in patent: Page/Page column 18-19
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2005, vol. 180, # 7, p. 1701 - 1712
[3] Journal fuer Praktische Chemie (Leipzig), 1928, vol. <2> 119, p. 351
[4] Journal of the Chemical Society, 1929, p. 2368
[5] Journal of the Chemical Society, 1930, p. 1110

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