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CIS-NEROLIDOL

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CIS-NEROLIDOL Basic information

Product Name:
CIS-NEROLIDOL
Synonyms:
  • CIS-NEROLIDOL
  • CIS-3,7,11-TRIMETHYL-1,6,10-DODECATRIEN-3-OL
  • (Z)-nerolidol,(6Z)-3,7,11-trimethyl-1,6,10-dodecatrien-3-ol,cis-nerolidol
  • NEROLIDOL, cis-(SG)
  • CIS-NEROLIDOL WITH GC
  • (6Z)-3,7,11-Trimethyl-1,6,10-dodecatriene-3-ol
  • (Z)-3,7,11-Trimethyl-1,6,10-dodecatrien-3-ol
  • Einecs 223-263-5
CAS:
3790-78-1
MF:
C15H26O
MW:
222.37
EINECS:
223-263-5
Mol File:
3790-78-1.mol
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CIS-NEROLIDOL Chemical Properties

Boiling point:
70 °C0.1 mm Hg(lit.)
Density 
0.876 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.478(lit.)
Flash point:
96℃
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless
Odor
at 100.00 %. waxy floral
Odor Type
waxy
BRN 
1724137
LogP
4.682 (est)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3

MSDS

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CIS-NEROLIDOL Usage And Synthesis

Uses

cis-Nerolidol is one of the main component in the essential oils from fresh aerial parts of Thymus ciliatus (Lamiaceae). Also, it is a terpene that displays high potency on the contractility of cardiac muscle in guinea pig left atrium. A potential and effective treatment for malaria.

Definition

ChEBI: (6Z)-nerolidol is a nerolidol in which the double bond at position 6 adopts a cis-configuration.

Purification Methods

1 2 2o/3mm, d 4 0.73, n D 1.477, [cis 3790-78-1] b 70o/0.1mm, [trans 40716-66-3] b 78o/0.2mm, 145-146o/2mm. Purify it by TLC on plates of Kieselguhr G [McSweeney J Chromatogr 17 183 1965] or silica gel impregnated with AgNO3, using 1,2-CH2Cl2/CHCl3/EtOAc/PrOH (10:10:1:1) as solvent system. Also by GLC on butanediol succinate (20%) on Chromosorb W. Stored it under N2 at ~5o in the dark. [Beilstein 1 IV 2336.]

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