PL017
PL017 Basic information
- Product Name:
- PL017
- Synonyms:
-
- (N-ME-PHE3,D-PRO4)-BETA-CASOMORPHIN (1-4) AMIDE (BOVINE)
- [N-ME-PHE3, D-PRO4]-MORPHICEPTIN
- [(NME)PHE3, DPRO4] MORPHICEPTIN, BOVINE
- PL017
- TYR-PRO-(NME)PHE-DPRO-NH2
- H-TYR-PRO-N-ME-PHE-D-PRO-NH2
- {N-METHYL-PHE3,D-PRO4}-BETA-CASOMORPHIN FRAGMENT 1-
- [n-methyl-phe3, d-pro4]-β-casomorphin fragment 1-4 amide, bovine
- CAS:
- 83397-56-2
- MF:
- C29H37N5O5
- MW:
- 535.63
- Mol File:
- 83397-56-2.mol
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PL017 Chemical Properties
- Boiling point:
- 878.5±65.0 °C(Predicted)
- Density
- 1.313±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Powder
- pka
- 9.86±0.15(Predicted)
- Water Solubility
- Soluble to 1 mg/ml in water
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
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PL017 Usage And Synthesis
Biological Activity
PL-017 is a potent and selective μ opioid receptor agonist with IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ site. PL-017 produces durable and reversible analgesia in rats.
in vitro
PL-017 has an IC 50 of 10000 nM for 125 I-DADLE binding to δ site.
in vivo
PL-017 (0.22, 0.45, 0.9 nmol/rat; icv) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.
target
IC50: 5.5 nM ( 125 I-FK 33,824 binding to μ site)
PL017Supplier
GL Biochem (Shanghai) Ltd
- Tel
- 21-61263452 13641803416
- ymbetter@glbiochem.com
Shanghai Hanhong Scientific Co.,Ltd.
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
- Tel
- 021-50135380
- shchemsky@sina.com
Nanjing Leon Biological Technology Co., Ltd.
- Tel
- 17705183659
- sales@njleonbiotech.com
Nanjing Peptide Biotech Ltd.
- Tel
- 025-025-58361106-805-805 13082558573
- liugang@njpeptide.com