Piclamilast
Piclamilast Basic information
- Product Name:
- Piclamilast
- Synonyms:
-
- Benzamide,3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
- RP 73401
- RPR 73401
- 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide
- 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
- N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide
- Piclamilast
- 3-(Cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
- CAS:
- 144035-83-6
- MF:
- C18H18Cl2N2O3
- MW:
- 381.25
- Product Categories:
-
- Aromatics
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 144035-83-6.mol
Piclamilast Chemical Properties
- Boiling point:
- 447.8±45.0 °C(Predicted)
- Density
- 1.370
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- pka
- 10.10±0.70(Predicted)
- form
- powder
- color
- white to beige
Piclamilast Usage And Synthesis
Uses
Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor. Piclamilast may offer therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease. Piclamilast may also provide a treatment option for pre-term infants with bronchopulmonary dysplasia (BPD).
Definition
ChEBI: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
Biological Activity
Piclamilast is a potent and selective cyclic AMP phosphodiesterase-4 inhibitor th at exhibits equal, high affinity for both the PDE4 high- and low-affinity rolipram binding states (HARBS and LARBS). Recent studies shown th at piclamilast inhibits Trypanosoma brucei PDEB1 (TbrPDEB1) and TbrPDEB2.', 'Piclamilast is also known as N-(3,5-dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Piclamilast regulates the cAMP (cyclic adenosine monophosphate) signaling pathway. It increases the retinoid-dependent transactivation and the degradation of retinoic acid receptor α (RARα).
storage
Store at RT
PiclamilastSupplier
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- 010-82848833 400-666-7788
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- 86(21)68097365
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- 021-54581719 13817873692
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Piclamilast(144035-83-6)Related Product Information
- 3-ISOPROPOXY-4-METHOXY-BENZALDEHYDE
- 4-Benzylaminopyridine
- 3-ETHOXY-4-METHOXY-BENZYLAMINE
- 3-BUTOXY-4-METHOXYBENZAMIDE
- N1-(4-PYRIDYL)BENZAMIDE
- 3-CYCLOPENTYLOXY-4-METHOXYBENZALDEHYDE
- CHEMBRDG-BB 9071037
- (3,5-DICHLORO-PYRIDIN-4-YL)METHYLAMINE
- 3-ISOPROPOXY-BENZALDEHYDE
- Piclamilast
- BENZYL-PYRIDIN-4-YL-AMINE DIHYDROCHLORIDE
- 3-(SEC-BUTOXY)PHENYL]METHANAMINE
- 3-(CYCLOPENTYLOXY)-4-METHOXYBENZAMIDE
- 3-(CYCLOPENTYLOXY)BENZALDEHYDE
- CHEMBRDG-BB 5563263
- 1-(3-ISOPROPOXYPHENYL)METHANAMINE