althiomycin Chemical Properties

Melting point:

172-174 °C (decomp)

Density 

1.72±0.1 g/cm3(Predicted)

storage temp. 

-20°C

pka

9.67±0.10(Predicted)

form 

A crystalline solid

althiomycin Usage And Synthesis

Uses

Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.

References

[1] Gerc, et al. The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin. PLoS One 7(9), e44673 (2012).

althiomycin(12656-40-5)Related Product Information

• 4-METHOXY-3-PYRROLIN-2-ONE
• 2-ethyl-4,5-dihydrothiazole
• althiomycin