paraherquamide Chemical Properties

Melting point:

244-247° (dec)

alpha 

D22 -28° (c = 0.43 in methanol)

storage temp. 

Store at -20°C

solubility 

DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble

form 

White to off-white powder.

paraherquamide Usage And Synthesis

Description

Paraherquamide A is a mycotoxin anthelmintic originally isolated from P. paraherquei. It binds to acetylcholine receptors (IC₅₀ = 0.5 nM for head homogenates of M. domestica) and acts as an antagonist. Paraherquamide A is toxic to C. elegans (LD₅₀ = 2.5 μg/ml) and effective against T. colubriformis infection in gerbils when used at doses ranging from 0.39 to 200 mg/kg. It is toxic to mice (LD₅₀ = 14.9 mg/kg).

Uses

Paraherquamide A was first reported as a mycotoxin related to the indole tremorgenic mycotoxins. Subsequent research identified a potent, non-toxic paralysis of nematodes which led to the metabolite's development as a candidate anthelmintic. Paraherquamide A is a selective, competitive, cholinergic antagonist that distinguishes subtypes of cholinergic receptors.

Uses

Paraherquamide A is a selective, competitive, cholinergic antagonist.

paraherquamide(77392-58-6)Related Product Information

• 3-Isobutyl-2-oxindole
• 2-Amino-2,3-dimethylbutyramide
• trans-2,5-Dimethylpiperazine
• 6-Methoxy-2-oxindole
• (S)-3-Aminopiperidine
• 2,5-Diazabicyclo[2.2.2]octane
• 7-METHOXYOXINDOLE
• (1,4-DIMETHYL-2-PIPERAZINYL)METHANOL
• (S)-2-HYDROXYMETHYL-PIPERAZINE
• N-[1-(aminomethyl)cyclopentyl]-N,N-dimethylamine
• (1S,4S)-2,5-DIAZABICYCLO(2.2.2)OCTANE
• 7-METHOXY-2,3-DIHYDRO-1H-INDOLE
• [1-(3,4-DIMETHOXYPHENYL)CYCLOPENTYL]METHANAMINE
• R-2-ISOPROPYL-PIPERAZINE
• Piperazine, 1,2,2-trimethyl- (9CI)
• 1,2-BIS(DIMETHYLAMINO)-2-METHYLPROPANE
• 2-PIPERIDIN-3-YLPROPAN-2-OL
• N'-CYCLOPENTYL-N,N-DIMETHYL-ETHANE-1,2-DIAMINE