Basic information Safety Supplier Related

PD 124966

Basic information Safety Supplier Related

PD 124966 Basic information

Product Name:
PD 124966
Synonyms:
  • PD 124966
  • 18-Hydroxy-48-demethoxy-33β-methyl-43-[(S)-1-methylpropyl]-33-de[(3S,1E,5E)-3-ethyl-1,5-dimethyl-4-oxo-1,5-heptadienyl]-52-deoxy-42,50,51,53-tetranorazinothricin
  • L-156602
CAS:
107231-21-0
MW:
0
Mol File:
Mol File
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PD 124966 Usage And Synthesis

Uses

L 156602 is a cyclic hexapeptide isolated from a strain of Streptomyces by researchers at Merck USA and reported in 1991. L 156602 belongs to the aurantimycin class and, like other members, is active against Gram positive bacteria. L 156602 was foremost discovered as a competitive binding inhibitor of the inflammatory peptide, C5a, to cell surface receptors on macrophages. In vivo, L 156602 profoundly suppresses footpad edema induced by concanavalin A and completely suppresses the infiltration of mononuclear leukocytes and neutrophils into the site of inflammation.

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