LAVENDUSTIN C Chemical Properties

Melting point:

193-195°C dec.

Boiling point:

597.5±50.0 °C(Predicted)

Density 

1.551±0.06 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

DMSO: soluble

form 

solid

pka

2.32±0.10(Predicted)

color 

Light Beige to Brown

Stability:

Hygroscopic

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:SigmaAldrich

LAVENDUSTIN C Usage And Synthesis

Description

Lavendustin C, a derivative of a Streptomyces griseolavendus butyl acetate extract, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC₅₀ value of 0.012 μM. Lavendustin C also inhibits pp60^c-src(+) kinase and Ca²⁺ calmodulin-dependent kinase II with IC₅₀ values of 0.5 and 0.2 μM, respectively. At a concentration of 10-150 μM, lavendustin C inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

Chemical Properties

Brown Solid

Uses

Shows potent tyrosine kinase inhibitory activity.

Definition

ChEBI: 5-[(2,5-dihydroxyphenyl)methylamino]-2-hydroxybenzoic acid is an aromatic amine.

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