LAVENDUSTIN A
LAVENDUSTIN A Basic information
- Product Name:
- LAVENDUSTIN A
- Synonyms:
-
- RG14355
- LAVENDUSTIN A
- 5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID
- 5-[[(2,5-DIHYDROXYPHENYL)METHYL][(2-HYDROXYPHENYL)METHYL]AMINO]-2-HYDROXYBENZOIC ACID
- Lavendustin A - CAS 125697-92-9 - Calbiochem
- RG-14355;NSC 678027
- 5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid
- Lavendustin A,98%
- CAS:
- 125697-92-9
- MF:
- C21H19NO6
- MW:
- 381.38
- Product Categories:
-
- Miscellaneous Natural Products
- All Inhibitors
- Inhibitors
- Tyrosine Kinase Inhibitors
- Mol File:
- 125697-92-9.mol
LAVENDUSTIN A Chemical Properties
- Melting point:
- 205-215 °C
- Boiling point:
- 741.7±60.0 °C(Predicted)
- Density
- 1.495±0.06 g/cm3(Predicted)
- RTECS
- DG8578950
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- crystalline
- pka
- 2.31±0.10(Predicted)
- color
- Yellow to brown
- Sensitive
- Air Sensitive
- Stability:
- Moisture Sensitive: Hygroscopic
- CAS DataBase Reference
- 125697-92-9(CAS DataBase Reference)
MSDS
- Language:English Provider:ACROS
- Language:English Provider:SigmaAldrich
LAVENDUSTIN A Usage And Synthesis
Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
Chemical Properties
Off-White Solid
Uses
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
Definition
ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
target
EGFR | PKC | PI3K | Calcium Channel
LAVENDUSTIN ASupplier
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LAVENDUSTIN A(125697-92-9)Related Product Information
- METHYL 2,5-DIHYDROXYCINNAMATE
- H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH
- AG 825
- TYRPHOSTIN A25
- Canertinib
- Lavendustin C Analog, Methyl-4-[N-(2μ,5μ-dihydroxybenzyl)amino]benzoate,LAVENDUSTIN C ANALOG
- N,N-DIBENZYLANILINE
- 3-(Dimethylamino)benzoic acid
- Ethylbenzyltoluidine
- LAVENDUSTIN A
- 5-Dimethylamino-2-hydroxybenzaldehyde
- LAVENDUSTIN C
- 2-(BENZYLAMINO-METHYL)-PHENOLHYDROCHLORIDE
- 3-(DIETHYLAMINO)BENZOIC ACID
- LAVENDUSTIN B
- lavendustin C6
- LAVENDUSTIN C METHYL ESTER
- LAVENDUSTIN A METHYL ESTER