BMS-502
BMS-502 Basic information
- Product Name:
- BMS-502
- Synonyms:
-
- BMS-502
- BMS-502 (Compound 22)
- BMS-502（SCHEMBL21830991）
- 8-(4-(Bis(4-fluorophenyl)methyl)piperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile
- CAS:
- 2407854-18-4
- MW:
- 0
- Mol File:
- 2407854-18-4.mol
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BMS-502 Chemical Properties
- form
- Solid
- color
- Light yellow to yellow
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BMS-502 Usage And Synthesis
Definition
BMS-502 is a dual DGKα and ζ inhibitor. BMS-502 demonstrated dose-dependent immune stimulation in the mouse OT-1 model, setting the stage for a drug discovery program. BMS-502 demonstrated substantial inhibitory activity against DGKs α, ζ and ι[1].
References
[1] Louis Chupak* and Susan Wee. “Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization.” ACS Medicinal Chemistry Letters 14 7 (2023): 929–935.
BMS-502Supplier
Hubei Chuchang Chemical Co., Ltd Gold
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Shanghai EFE Biological Technology Co., Ltd.
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ShangHai Biochempartner Co.,Ltd
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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