NC 182 Usage And Synthesis

Description

NC182 is a topo II inhibitor. NC182 exhibits selective and superior topo II inhibition upon induction of topo II-dependent DNA fragmentation.

Uses

NC-182 is an anti-tumor agent and DNA intercalator with a preference for B-form DNA. NC-182 can also promote the unwinding of Z-form DNA to B-form. NC-182 has a potent inhibitory effect on multidrug-resistant and sensitive tumors.

References

[1] DNA-binding characterization of a novel anti-tumour benzo[a]phenazine derivative NC-182: spectroscopic and viscometric studies

NC 182(106224-67-3)Related Product Information

• 5-METHYLQUINOXALINE
• (6-HYDROXYMETHYL)QUINOXALINE
• 6-METHOXYQUINOXALINE
• (5-METHOXY-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL)-ACETIC ACID
• NC 182
• QUINOXALINE-6-CARBALDEHYDE
• METHYL 6-QUINOXALINECARBOXYLATE
• 6-Hydroxyquinoxaline
• 6-QUINOXALINECARBOXYLIC ACID