simvastatin acid
simvastatin acid Basic information
- Product Name:
- simvastatin acid
- Synonyms:
-
- (3R,5R)-3,5-Dihydroxy-7-[(1S)-1-(2,2-dimethylbutyryloxy)-3β,7α-dimethyl-1,2,3,7,8,8aα-hexahydronaphthalene-8α-yl]heptanoic acid
- (βR,δR,1S)-8α-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8aβ-hexahydro-β,δ-dihydroxy-2β,6α-dimethyl-1β-naphthaleneheptanoic acid
- 2,2-Dimethylbutanoic acid [(1S)-1,2,3,7,8,8aα-hexahydro-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]naphthalen]-1β-yl ester
- 2,2-Dimethylbutyric acid (1S)-3β,7α-dimethyl-8α-[(3R,5R)-3,5-dihydroxy-6-carboxyhexyl]-1,2,3,7,8,8aα-hexahydronaphthalene-1β-yl ester
- Simvastatin hydroxy acid
- (3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, (βR,δR,1S,2S,6R,8S,8aR)-
- Tenivastatin
- CAS:
- 121009-77-6
- MF:
- C25H40O6
- MW:
- 436.585
- Mol File:
- 121009-77-6.mol
simvastatin acid Chemical Properties
- Boiling point:
- 607.0±55.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- pka
- 4.31±0.10(Predicted)
- EPA Substance Registry System
- 1-Naphthaleneheptanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-?,?-dihydroxy-2,6-dimethyl-, (?R,?R,1S,2S,6R,8S,8aR)- (121009-77-6)
simvastatin acid Usage And Synthesis
Uses
Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
Definition
ChEBI: Simvastatin hydroxy acid is a carbonyl compound.
References
[1] Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. DOI:10.1080/13543776.2016.1216977
[2] Atilano-Roque A, et al. Characterization of simvastatin acid uptake by organic anion transporting polypeptide 3A1 (OATP3A1) and influence of drug-drug interaction. Toxicol In Vitro. 2017 Dec;45(Pt 1):158-165. DOI:10.1016/j.tiv.2017.09.002
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simvastatin acid(121009-77-6)Related Product Information
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- SIMVASTATIN, SODIUM SALT
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- 6'-HYDROXYCARBOXY SIMVASTATIN ACID DISODIUM SALT
- 6'-HYDROXYMETHYL SIMVASTATIN ACID SODIUM SALT
- SIMVASTATIN HYDROXY ACID SODIUM SALT-D6
- simvastatin acid
- 3''-HYDROXY SIMVASTATIN ACID SODIUM SALT
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- SIMVASTATIN-D6 HYDROXY ACID, AMMONIUM SALT