Bimosiamose
Bimosiamose Basic information
- Product Name:
- Bimosiamose
- Synonyms:
-
- Bimosiamose
- TBC-1269
- [1,1'-Biphenyl]-3-acetic acid, 3',3'''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-
- CAS:
- 187269-40-5
- MF:
- C46H54O16
- MW:
- 862.92
- Mol File:
- 187269-40-5.mol
Bimosiamose Chemical Properties
- Melting point:
- 115-117°
- Boiling point:
- 1051.0±65.0 °C(Predicted)
- Density
- 1.417±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);115.89(Max Conc. mM)
0.1 M NaOH:25.0(Max Conc. mg/mL);28.97(Max Conc. mM) - form
- A crystalline solid
- pka
- 3.95±0.10(Predicted)
- color
- White to off-white
Bimosiamose Usage And Synthesis
Uses
Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1].
in vivo
Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].
| Animal Model: | Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1] |
| Dosage: | 25 mg/kg |
| Administration: | Intravenous injection |
| Result: | Showed a significant increase in survival compared with controls. |
References
[1] Palma-Vargas JM, et al. Small-molecule selectin inhibitor protects against liver inflammatory response after ischemia and reperfusion. J Am Coll Surg. 1997 Oct;185(4):365-72. PMID:9328385
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