BUTTPARK 83\09-70 Chemical Properties

Melting point:

106 °C

Boiling point:

384.9±42.0 °C(Predicted)

Density 

1.300±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

pka

7.18±0.42(Predicted)

Appearance

Light yellow to yellow Solid

BUTTPARK 83\09-70 Usage And Synthesis

Synthesis

Preparative Example 1 Synthesis of 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine: in a dry reaction flask, 3-chloro-4-fluoronitrobenzene (10.05 g, 57.2 mmol) was mixed with N-methylpiperazine (17.2 g, 172 mmol). Exothermic phenomenon was observed during the reaction and after 1 h of continuous stirring, the reaction mixture was quenched by adding water to the reaction mixture. The resulting brown solid precipitate was collected by filtration and washed with plenty of water to remove unreacted raw materials and by-products. Finally, the product was dried in air to afford 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine (14.1 g, 96% yield). The product was confirmed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (MS) characterization: 1H NMR δ 2.24 (s, 3H), 2.43-2.55 (m, 4H), 3.11-3.24 (m, 4H), 7.28 (d, J = 9.03 Hz, 1H), 8.14 (dd, J = 9.03,2.76 Hz, 1H) , 8.21 (d, J = 2.51Hz, 1H); MS m/z 255 (M+).

References

[1] Patent: WO2011/120026, 2011, A1. Location in patent: Page/Page column 34-35
[2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1997, vol. 36, # 4, p. 347 - 348
[3] Patent: WO2016/22460, 2016, A1. Location in patent: Page/Page column 137
[4] Patent: WO2017/66428, 2017, A1. Location in patent: Page/Page column 249