5-METHYL-2H-ISOQUINOLIN-1-ONE Chemical Properties

Boiling point:

400.5±45.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.12±0.20(Predicted)

Appearance

Light yellow to yellow Solid

5-METHYL-2H-ISOQUINOLIN-1-ONE Usage And Synthesis

Synthesis

Synthesis of Intermediate-3: 5-Methylisoquinolin-1(2H)-one: o-Methylcinnamoyl azide (Intermediate-2) (10 g, 53.5 mmol) was dissolved in toluene (100 mL) with stirring and heated to 110±2°C for 1 hour. After completion of the reaction, the toluene solvent was removed under reduced pressure, 1,2-dichlorobenzene (DCB) (100 mL) and iodine (catalytic amount) were added, and the reaction mixture was heated to 180±2°C and kept reacting overnight. At the end of the reaction, the solvent was removed under reduced pressure and the product was purified by recrystallization (ethyl acetate: hexane = 90:10) to afford the target compound 5-methylisoquinolin-1(2H)-one (4 g, 45% yield).

References

[1] Patent: US2013/178457, 2013, A1. Location in patent: Paragraph 0175
[2] Patent: WO2013/5168, 2013, A2. Location in patent: Page/Page column 33
[3] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 8, p. 1147 - 1156
[4] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 4, p. 961 - 964

5-METHYL-2H-ISOQUINOLIN-1-ONE(24188-72-5)Related Product Information

• 5-Methylquinoline
• 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• 5-methyl-2-Indolinone
• ETHYL 5-METHYLOXAZOLE-4-CARBOXYLATE
• 5-METHYL-4-QUINAZOLONE
• 2-Pyrimidinecarboxylic acid, 5-methyl- (6CI,9CI)
• 5-Methylquinoline-8-carboxylic acid
• 5-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID
• 5-METHYL-IMIDAZO[1,2-A]PYRIDINE
• AURORA KA-3366
• 5-METHYL-2H-ISOQUINOLIN-1-ONE
• (S)-2-(1-AZA-BICYCLO[2.2.2]OCT-3-YL)-2,4,5,6-TETRAHYDRO-BENZO[DE]ISOQUINOLIN-1-ONE