1-Hydroxymethyl-1,2,4-triazole Chemical Properties

Melting point:

70-71℃

Boiling point:

290℃

Density 

1.42

Flash point:

129℃

storage temp. 

Inert atmosphere,Room Temperature

pka

11.58±0.10(Predicted)

Appearance

White to off-white Solid

1-Hydroxymethyl-1,2,4-triazole Usage And Synthesis

Uses

1-Hydroxymethyl-1,2,4-triazole is useful in the synthesis of novel triazole compounds that have anti-fungal properties.

Synthesis

Step 1. Preparation of (1H-1,2,4-triazol-1-yl)methanol 1H-1,2,4-triazole (7.04 g, 102 mmol) was mixed with paraformaldehyde (3.06 g, 102 mmol) and catalytic amount of triethylamine was added. The mixture was heated to a molten state (140°C) and stirred at this temperature for 0.5 hours. After completion of the reaction, the reaction mixture was cooled to 30 °C to give a white solid product (9.0 g, 89% yield).

References

[1] Heterocyclic Communications, 2001, vol. 7, # 6, p. 577 - 582
[2] Phosphorus and Sulfur and the Related Elements, 1987, vol. 33, p. 41 - 52
[3] Tetrahedron, 2010, vol. 66, # 47, p. 9145 - 9150
[4] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1980, vol. 16, # 2, p. 189 - 194
[5] Khimiya Geterotsiklicheskikh Soedinenii, 1980, vol. 16, # 2, p. 251 - 256

1-Hydroxymethyl-1,2,4-triazole(74205-82-6)Related Product Information

• Bitertanol
• 7-HYDROXY-5-METHYL-2-METHYLTHIO-S-TRIAZOLO[1,5-A]PYRIMIDINE
• Triadimenol
• Triadimefon
• 1-Hydroxymethyl-1,2,4-triazole
• 7-Hydroxy-5-methyl-1,3,4-triazaindolizine
• TARIBAVIRIN
• 2-AMINO-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL
• (7-HYDROXY-5-METHYL-[1,2,4]TRIAZOLO-[1,5-A]PYRIMIDIN-2-YL)-ACETIC ACID
• CHEMBRDG-BB 5560222
• 1-TERT-BUTOXYCARBONYL-1,2,4-TRIAZOLE
• 6-bromo-5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7-ol
• CHEMBRDG-BB 9071140
• 2-BENZYLSULFANYL-7-HYDROXY-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLIC ACID ETHYL ESTER
• 2-BENZYLSULFANYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL
• ethyl [(7-hydroxy-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)sulfanyl]acetate
• BUTTPARK 125\40-16
• 2-BENZYLSULFANYL-5-METHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-OL