(4-FLUORO-3-NITROPHENYL)ACETIC ACID Chemical Properties

Boiling point:

391.2±27.0 °C(Predicted)

Density 

1.498±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

4.01±0.10(Predicted)

Appearance

Light yellow to yellow Solid

(4-FLUORO-3-NITROPHENYL)ACETIC ACID Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-nitro-4-fluorophenylacetic acid from 4-fluorophenylacetic acid: to a solution of concentrated sulfuric acid (20 mL) of 4-fluorophenylacetic acid (3 g, 19.46 mmol) was added drop by drop of nitric acid (0.913 mL, 20.44 mmol) at 0 °C, and the reaction was stirred for 1 hour. After completion of the reaction, the mixture was slowly poured into ice water and extracted with dichloromethane (DCM, 2 x 20 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to dryness under reduced pressure to give 3-nitro-4-fluorophenylacetic acid (3.48 g, 90% yield). Mass spectrum (ESI) m/z: 198.1 ([M-H]+).

References

[1] Patent: WO2013/134298, 2013, A1. Location in patent: Page/Page column 35
[2] Patent: WO2018/116107, 2018, A1. Location in patent: Page/Page column 25-26
[3] Patent: WO2004/89912, 2004, A1. Location in patent: Page 25
[4] Patent: US6218547, 2001, B1
[5] Patent: WO2013/131408, 2013, A1. Location in patent: Page/Page column 59

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